When a cell shows accumulation of structure less
eosinophilic homogeneous material or hyaline material , it is described as
hyaline degeneration . This denotes a physical changes rather than a chemical
changes of the cell .
Mechanism ……
Hyalinisation is a
kind of coagulation of protein of a cell where the cell will be injured with
irrepairable damage to the mitochondria and ultimately there will be the
development of a strutureless , glassy , rigid but highly fragile material .
This irrepairable damage of the cell will lead to the death of the affected
cell . So, this may be described as Hyaline necrosis .
Cells affected in Hyaline degeneration …..
1.. Epithelial tissue
cells …
a) Epithelial
cells of renal tubules
b) Liver
cells
c) Epithelial
cells of prostate .
d) Middle
coat of the vessels wall
2.. Connective tissue cells;….
a) Fibrous
tissue
b) Tumours
like fibroid of uterus .
c) Wall
of the small intestine in arteriosclerosis .
d) Muscle- Hyaline degeneration may be found in rectus abdominis
and diaphragmatic muscles due to the action of toxin or excess accumulation of
lactic acid in typhoid , pneumonia , diphtheria and well’s disease . It
isdesxcribed as Zenker’s degeneration .
e) Thrombus
, infarct etc
f)
RTeticulum of lymphnodeas in chronic inflammatory
change .
